Malaria chemotherapy: Resistance to quinoline containing drugs inPlasmodium falciparum
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چکیده
منابع مشابه
Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs
Building on our earlier work of attaching a chemosensitizer (reversal agent) to a known drug pharmacophore, we have now expanded the structure-activity relationship study to include simplified versions of the chemosensitizer. The change from two aromatic rings in this head group to a single ring does not appear to detrimentally affect the antimalarial activity of the compounds. Data from in vit...
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We reported two cases of complicated falciparum malaria who had poor response to artesunate with delayed parasite clearance times. They were splenectomized patients who were treated with high doses of artemisinin derivatives. Our cases showed the importance of the spleen in the clearance of malaria parasites and had different clinical outcome, one fatal and one recovery. The host factors, the p...
متن کاملMicrosoft Word - 50
Development of new and more powerful antimalarial drugs has become more complex because of emergence of multidrug resistant strains of P. falciparum. Due to resistance of malaria parasite against well-known available drugs, the chemotherapy of malaria has become more complex and challenging. In this review we have discussed the life cycle of malaria parasite followed by quinoline based antimala...
متن کاملEconomic access to effective drugs for falciparum malaria.
The increasing death toll from drug-resistant falciparum malaria is cause for international concern. In 2002, the US Agency for International Development commissioned the Institute of Medicine (IOM) to recommend global actions to ensure the broadest possible access to new, effective antimalarial treatments. In a report issued in 2004, the IOM Committee on Economics of Antimalarial Drugs recomme...
متن کاملArtemisinin resistance in Plasmodium falciparum malaria.
BACKGROUND Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease. There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance. METHODS In two open-label, randomized trials, we compared the efficacies o...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1993
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.1993.tb06479.x